The Benefits of Aesthetic Exosomes Versus Salmon Sperm in Polynucleotide facial treatments.
- Chris Beckett
- Jan 1
- 3 min read
Facial treatments have evolved dramatically, offering new ways to enhance skin health and appearance. Among the latest innovations, aesthetic exosomes and salmon sperm polynucleotides stand out as promising options. Both are used to improve skin texture, hydration, and overall radiance, but they work differently and offer unique benefits. Understanding these differences can help you choose the best treatment for your skin care goals.

What Are Aesthetic Exosomes?
Exosomes are tiny vesicles released by cells that carry proteins, lipids, and genetic material. In aesthetics, exosomes are harvested from stem cells and used to promote skin regeneration. They act as messengers, delivering signals that encourage skin cells to repair and renew themselves.
How Exosomes Work in Skin Care
Cell communication: Exosomes transfer growth factors and microRNAs to skin cells, stimulating collagen production and reducing inflammation.
Skin repair: They help repair damaged skin by promoting cell turnover and healing.
Hydration and texture: Exosomes improve skin hydration and smoothness, leading to a youthful glow.
Because exosomes come from human stem cells, they closely mimic natural skin processes, making them highly effective in aesthetics treatments.
Understanding Salmon Sperm Polynucleotides in facial treatments
Salmon sperm polynucleotides (PN) are long chains of nucleotides extracted from salmon DNA. These molecules have been used in skin care for their regenerative and moisturizing properties. Polynucleotides support skin repair by providing building blocks for DNA and RNA synthesis in skin cells.
Benefits of Polynucleotide Treatments
Tissue regeneration: Polynucleotides stimulate fibroblast activity, which increases collagen and elastin production.
Anti-inflammatory effects: They reduce redness and irritation, improving sensitive skin conditions.
Moisture retention: Polynucleotides enhance the skin’s ability to retain water, improving elasticity and softness.

Salmon sperm PN treatments have gained popularity due to their natural origin and compatibility with human skin.
Comparing Aesthetic Exosomes and Salmon Sperm Polynucleotides
Both treatments aim to rejuvenate the skin but differ in their source, mechanism, and effects. Here’s a detailed comparison:
Category | Exosomes | Polynucleotides (PN / Salmon DNA) |
Source | Human stem cell–derived extracellular vesicles | Purified salmon sperm DNA |
Mechanism of action | Advanced cell signalling and communication, stimulating repair pathways | Supports DNA/RNA synthesis and cellular repair |
Key skin benefits | Boosts collagen and elastin, anti-inflammatory, accelerates tissue repair | Improves collagen production, hydration, skin barrier support, reduces redness |
Primary treatment goals | Skin regeneration, rejuvenation, anti-ageing | Skin repair, hydration, soothing, texture improvement |
Safety profile | Low risk, biocompatible when sourced and used correctly | Low risk, well-established, natural origin |
Treatment frequency | Typically fewer sessions required due to potency | Often delivered as a course of multiple sessions |
Table comparing exosomes and polynucleotides (salmon DNA) for skin regeneration and repair treatments.
Which One Is Better for Your Skin?
For aging skin: Exosomes may offer stronger collagen stimulation and faster results.
For sensitive or irritated skin: Polynucleotides provide soothing and hydration benefits.
For overall skin health: Both can be combined or alternated for comprehensive care.
Practical Considerations for Treatment
When choosing between aesthetic exosomes and salmon sperm polynucleotides, consider these factors:
Skin type and concerns: Identify your primary skin issues such as dryness, wrinkles, or sensitivity.
Treatment goals: Decide if you want rapid anti-aging effects or gentle skin repair.
Budget and availability: Exosome treatments can be more costly and less widely available.
Professional advice: Consult a licensed aesthetician or dermatologist to tailor the treatment to your needs.
Real-World Examples and Results
Many clinics report positive outcomes with both treatments. For example:
A 45-year-old client with fine lines and dull skin saw noticeable improvement in skin texture after three exosome sessions.
A client with rosacea experienced reduced redness and better hydration following a series of salmon sperm polynucleotide treatments.
These examples show how both options can enhance beauty and skin care when used appropriately.

Final Thoughts on Aesthetic Exosomes and Polynucleotide Treatments
Both aesthetic exosomes and salmon sperm polynucleotides offer valuable benefits for skin care and aesthetics. Exosomes provide powerful skin regeneration and anti-aging effects, while polynucleotides excel in hydration and soothing sensitive skin. Choosing the right treatment depends on your skin type, concerns, and goals.
To get the best results, work with a qualified professional who can recommend a personalized plan. Combining these treatments with a consistent skin care routine can help you achieve lasting beauty and healthy skin.
Book a consultation with our Dermalogica-trained practitioner for personalised advice on suitable treatment options.




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